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Myocardial Glutathione Alterations in Acute Coronary Occlusion in the Dog

1987

Glutathione (GSH) decreases in dog mycocardium upon acute coronary occlusion when compared with sham-operated dogs. Total glutathione content (GSHeq = GSH + ZGSSG) remains unchanged throughout the experiment (6 h after surgery) in both sham- and acute coronary occlusion-operated dogs. GSSG and GSH/GSSG ratio increases and decreases respectively in all animals but tends to reach the normal value after 6 h in sham-operated dogs. Both parameters (GSSG and GSH/GSSG ratio) remain altered in acute coronary occlusion-operated ones. This alteration of glutathione status in ischemic myocardium is discussed.

inorganic chemicalsmedicine.medical_specialtyIschemic myocardiumIschemiaCoronary DiseaseBiochemistrychemistry.chemical_compoundDogsfluids and secretionsReference ValuesInternal medicinemedicineAnimalsNormal rangeGlutathione DisulfideTotal glutathionebusiness.industryMyocardiumGlutathionemedicine.diseaseCoronary VesselsGlutathioneKineticschemistryCoronary occlusionAnesthesiaCardiologybusinessFree Radical Research Communications
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